Matthew P. Scott

Matthew P. Scott

Citizenship United States
Fields developmental biology
Institutions Stanford University
Alma mater M.I.T.
Doctoral advisor Mary Lou Pardue
Known for homeobox discovery

Matthew P. Scott is a developmental biologist and HHMI investigator at Stanford University studying how embryonic and later development is governed by proteins that control gene activity and cell signaling processes.[1] [2]

He independently discovered homeobox genes in Drosophila melanogaster working with Amy J. Weiner at the University of Indiana.[3][4]

Among his laboratory's many subsequent discoveries, he is recognized for the cloning of the patched gene family and demonstration that a human homolog PTCH1 is a key tumor suppressor gene for the Hedgehog signaling pathway as well as the causative gene for the nevoid basal cell carcinoma syndrome, or Gorlin syndrome.[5][6]

Biography

Scott served on the faculty of the Department of Molecular, Cellular, and Developmental Biology at the University of Colorado starting in 1983. He moved to Stanford University in 1990 to join the faculty of the Department of Developmental Biology and the Department of Genetics. From 2002-2007 he was Chair of Bio-X, Stanford's interdisciplinary biosciences program.[7]

He is married to Stanford developmental geneticist Margaret T. Fuller.

Awards

References

  1. ^ "Scott lab homepage at Stanford University". http://scottlab.stanford.edu/. Retrieved 2009-04-10. 
  2. ^ "HHMI Scientist Bio: Matthew P. Scott, Ph.D.". http://www.hhmi.org/research/investigators/scottm_bio.html. Retrieved 2009-04-10. 
  3. ^ Scott MP; Weiner AJ (1984). "Structural relationships among genes that control development: sequence homology between the Antennapedia, Ultrabithorax, and fushi tarazu loci of Drosophila". PNAS 81 (13): 4115–9. doi:10.1073/pnas.81.13.4115. PMC 345379. PMID 6330741. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=345379. 
  4. ^ Laughon, A; Scott MP (1984). "Sequence of a Drosophila segmentation gene: protein structure homology with DNA-binding proteins". Nature 310 (5972): 25–31. doi:10.1038/310025a0. PMID 6330566. 
  5. ^ Hooper JE, Scott MP. The Drosophila patched gene encodes a putative membrane protein required for segmental patterning. Hooper JE, Scott MP. Cell. 1989 Nov 17;59(4):751-65. PMID 2582494
  6. ^ Johnson RL, Rothman AL, Xie J, Goodrich LV, Bare JW, Bonifas JM, Quinn AG, Myers RM, Cox DR, Epstein EH Jr, Scott MP. Human homolog of patched, a candidate gene for the basal cell nevus syndrome. Science. 1996 Jun 14;272(5268):1668-71. PMID 8658145
  7. ^ "Biography: Matthew Scott". Center for Genetic Medicine, Northwestern University. http://www.cgm.northwestern.edu/cgm/Academics/Richard-A.-Scott-MD-Lecture-Series/Biography-Matthew-Scott. Retrieved 2009-04-10. 
  8. ^ "Scholar Profile, Matthew P. Scott". Searle Scholars program. http://www.searlescholars.net/person/384. Retrieved 2009-04-10.